University College London Cancer Institute and the University College Hospital form a leading UK Comprehensive Cancer Centre, combining basic cancer biology and translational research with delivering excellent cancer care. The research proposed within this application will be provided through the Radiotherapy Department and the Clinical Research Facility with support from the UCL Cancer Institute. It was awarded status of CRUK UCL-Manchester Lung Centre of Excellence in 2014 The Radiotherapy department is situated in the basement of University College London Hospital. The Department treats approximately 1800 patients a year. The equipment consists of: 5 Varian Linear Accelerators (Linacs), 4 of which have volumetric arc therapy facility, 4 with on-board imaging facilities and all with MLC’s and Portal Imaging, CT Simulator with Advantage Sim software, Orthovoltage treatment unit, HDR Brachytherapy theatre. UCLH offers stereotactic radiotherapy for cranial malignancies and early primary thoracic malignancies and is currently extending this technique to the management of oligometastastic disease at other sites. We have a working partnership with HCA having shared use of TrueBeam Linear Accelerator. UCLH was selected to host one of two Proton Beam Facilities in the UK and is planned to be clinically functional by 2018. The NIHR/Wellcome Clinical Research Facility is a state-of-the-art early phase trials unit dedicated to cancer drug development. Located on the ground floor of the University College Hospital, the unit provides twenty treatment spaces, clinic rooms, a pharmacy dispensary and a GCLP sample handling laboratory. A broad portfolio of academic and commercially sponsored early phase clinical trials are undertaken by specialist clinical staff, including first-in-man as well as tumour specific phase I and II trials. University College London (UCL) is one of the world’s leading universities and is renowned for its outstanding research and teaching. The university won the largest funding allocation from UK research councils in 2013. The UCL Cancer Institute is the hub for cancer research at UCL. The Institute is structured as five Departments (Oncology, Haematology, Pathology, Cancer Biology and the CR-UK UCL Clinical Trials Centre). It has a GCLP facility which contains a large assay lab for pharmacokinetic (PK) and pharmacodynamics studies, a lab for handling radioactive trial samples, a separate PCR lab, a monitored sample storage area, a microscope room and a clinical sample-handling lab which is linked to the Clinical Research Facility.