The Cliniques Universitaires Saint-Luc (CUSL – UCL) is one of the main academic hospitals of Brussels, and is currently treating the largest number of cancer patients in this region. CUSL has 3 main priorities: high quality care, education, and research in fundamental, translational and clinical fields. In this spirit, the radiotherapy department of the CUSL has been focusing for many years on the development, implementation and validation of novel radiotherapy technologies, including tumour motion management strategies, image-guided radiation therapy, dose painting with molecular imaging and Stereotactic Ablative Radiation Therapy. Two out of the 5 radiation oncologists are half-time research, and supervise 4 PhD students in the field of image-guidance and high precision radiation delivery techniques. Amongst the on-going research projects, we are currently leading 3 phase II trials on SABR in liver and lung primary tumours. The multidisciplinary team in charge of lung cancer patients (GOTH) consists of 14 medical and paramedical experts who collaborate to cover all aspects of patient management, from diagnosis to treatment and follow-up. Besides providing the highest quality of care, this team also participates to 11 academic and industry-sponsored phase I-to-3 clinical trials, of which 2 are related to SABR in early stage NSCLC, and 4 to immunotherapy in advanced stage NSCLC. All studies are coordinated by 2 dedicated data managers experienced in lung cancers.