OncoRay is an interdisciplinary research center established in 2005 and financed by the Technische Universität Dresden, the University Hospital Dresden and the Helmholtz-Zentrum Dresden- Rossendorf. OncoRay together with its sister institution HIRO Heidelberg has been nominated as National Center for Radiation Research in Oncology by the German Federal Ministry of Education and Research. It is located at the campus of the medical faculty in the heart of Dresden. OncoRay’s vision is to improve the treatment of cancer by means of biologically individualized, technically optimized radiotherapy. Focus and strategy are aimed at preclinical and clinical translational research.  Approximately 20% of all patients are included in clinical trials approved by an ethical committee and managed by our GCP compliant Data Centre. Translational research is one of our strengths and has resulted in the currently accrual of an industry-sponsored phase I clinical study. Between 2006 and 2013, the phase II IIT-study on FMISO-PET imaging has successfully been conducted and will be followed by a randomized image-guided dose-escalation study in advanced stage, HPV-negative head and neck squamous cell carcinoma patients. Finally, physics-related research, with particular emphasis on proton beam therapy, has gained international attention, e.g., prompt gamma imaging and timing. The Department of Radiation Oncology in Dresden offers state-of-the-art radiotherapy to more than 2500 cancer patients each year. It is equipped with a PET-CT and a PET-MR scanner besides CT scanners on all photon and proton beam accelerators.  https://tu-dresden.de/med/mf